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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK3
All Species:
42.12
Human Site:
S469
Identified Species:
66.19
UniProt:
O43781
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43781
NP_001004023.1
588
65714
S469
V
V
L
V
G
G
R
S
R
R
G
K
K
R
G
Chimpanzee
Pan troglodytes
XP_524527
588
65774
S469
V
V
L
V
G
G
R
S
R
R
G
K
K
R
G
Rhesus Macaque
Macaca mulatta
XP_001086117
588
65769
S469
V
V
L
V
G
G
R
S
R
R
G
K
K
R
G
Dog
Lupus familis
XP_537131
637
71340
S519
V
V
L
V
G
G
R
S
R
R
G
K
K
R
G
Cat
Felis silvestris
Mouse
Mus musculus
Q922Y0
586
65553
S468
V
V
L
L
G
G
R
S
R
R
G
K
K
R
G
Rat
Rattus norvegicus
Q4V8A3
586
65492
S468
V
V
L
L
G
G
R
S
R
R
G
K
K
R
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
S428
V
V
L
N
G
G
R
S
R
R
G
K
L
R
G
Chicken
Gallus gallus
Q5ZIU3
526
59419
S407
I
I
L
N
G
G
R
S
R
R
G
K
L
R
G
Frog
Xenopus laevis
NP_001088793
567
63329
S449
T
V
L
N
G
S
R
S
R
R
G
K
M
R
G
Zebra Danio
Brachydanio rerio
NP_001108400
581
65351
S460
I
V
L
N
G
S
R
S
R
R
G
K
M
R
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
S536
V
V
L
I
G
G
Q
S
R
R
G
K
Q
R
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023207
817
89866
K698
A
R
T
F
I
T
S
K
G
Y
P
R
Y
C
T
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
P442
Y
C
T
V
T
T
L
P
D
G
T
T
V
L
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
E352
L
E
H
L
A
M
M
E
R
V
L
G
P
L
P
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
I651
W
R
K
L
P
D
I
I
R
N
Y
R
Y
P
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
85.7
N.A.
89.6
90.8
N.A.
57.9
59
65.3
63.4
N.A.
39
N.A.
40.5
54.7
Protein Similarity:
100
99.4
99.4
88.8
N.A.
93.5
94.2
N.A.
70.7
71.9
77.8
76.6
N.A.
50.9
N.A.
52.5
68.3
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
86.6
73.3
73.3
73.3
N.A.
80
N.A.
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
86.6
86.6
73.3
80
N.A.
100
N.A.
6.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.2
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
41
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
7
0
0
0
0
0
0
0
0
0
0
0
7
0
% C
% Asp:
0
0
0
0
0
7
0
0
7
0
0
0
0
0
0
% D
% Glu:
0
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
74
60
0
0
7
7
74
7
0
0
74
% G
% His:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
14
7
0
7
7
0
7
7
0
0
0
0
0
0
0
% I
% Lys:
0
0
7
0
0
0
0
7
0
0
0
74
40
0
7
% K
% Leu:
7
0
74
27
0
0
7
0
0
0
7
0
14
14
0
% L
% Met:
0
0
0
0
0
7
7
0
0
0
0
0
14
0
0
% M
% Asn:
0
0
0
27
0
0
0
0
0
7
0
0
0
0
7
% N
% Pro:
0
0
0
0
7
0
0
7
0
0
7
0
7
7
7
% P
% Gln:
0
0
0
0
0
0
7
0
0
0
0
0
7
0
0
% Q
% Arg:
0
14
0
0
0
0
67
0
87
74
0
14
0
74
0
% R
% Ser:
0
0
0
0
0
14
7
74
0
0
0
0
0
0
0
% S
% Thr:
7
0
14
0
7
14
0
0
0
0
7
7
0
0
7
% T
% Val:
54
67
0
34
0
0
0
0
0
7
0
0
7
0
0
% V
% Trp:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
0
0
7
7
0
14
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _